LAUSR

https://e-kcj.org Acute ischemic stroke (AIS) is a major cause of disability and mortality globally.1) Even after successful recovery from AIS, long-term clinical outcome of AIS is poor. Cardiovascular disease is 1 of the main determinants of long-term outcome in patients after AIS.2)3) By the improvement in primary prevention, diagnosis and therapy, there has been a considerable improvement in stroke prognosis for last several decades. However, stroke is still on the second place on mortality list following ischemic heart disease, and prevalence of AIS is expected to continuously increase with the increase in the aging population.1) Therefore, risk stratification and individualized therapy of patients with AIS is of paramount importance for clinicians to reduce their cardiovascular risk and overall prognosis. In this purpose, modifiable lifestyle risk factors such as smoking, heavy alcohol use and physical inactivity, and traditional risk factors such as hypertension, diabetes mellitus, dyslipidemia and smoking have been focused as treatment targets in patients with AIS.4) However, this strategy focusing on vascular risk factors may be insufficient, and overall stroke burden has greatly increased last decades. In this context, additional approach identifying high-risk patients based on reliable marker is required for targeted aggressive secondary prevention treatment.