LAUSR

https://e-kcj.org Contrast induced nephropathy (CIN) occurs sometimes and is presumed to influence on the clinical outcomes. Accordingly, lots of interventional methods with medication or device have been tried.1)2) Among them, peri-procedural hydration, contrast dose reduction and selection of contrast are suggested as cornerstone for preventing of CIN.3) Regarding the contrast media, there have been controversies whether iso-osmolar contrast media (IOCM) is superior to low-osmolar contrast media (LOCM) although both are widely used in coronary procedures. IOCM has same osmolality as that of blood (290 mOsm/kg H2O) and the LOCM has higher one than that of blood (600–900 mOsm/kg H2O). “Low-osmolar” means the lowered osmolality as compared to that of previously developed high-osmolar contrast media (1,500–2,000 mOsm/kg H2O) which are no longer used for their adverse effect including higher CIN rate. In other words, the term of “low” may come from the development history of contrast media, i.e., LOCM comes earlier than IOCM (currently iodixanol is the only one) which has same osmolality as blood.