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Vascular Calcification in Chronic Kidney Disease: Distinct Features of Pathogenesis and Clinical Implication

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Author's summary Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD) and leads to increased cardiovascular morbidity and mortality. In patients with CKD, traditional factors do… Click to show full abstract

Author's summary Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD) and leads to increased cardiovascular morbidity and mortality. In patients with CKD, traditional factors do not fully explain the high prevalence of VC. This suggests that a CKD-specific pathobiology is involved in the development of VC and mounting evidence indicates that VC in CKD patients has distinct features of clinical presentation and that clinical implications are changed compared to those in the general population. In this review, we discuss the mechanism, diagnostic imaging modalities, clinical features and implications, and management of VC in patients with CKD.

Keywords: distinct features; kidney disease; vascular calcification; chronic kidney

Journal Title: Korean Circulation Journal
Year Published: 2021

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