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To cite: Tamura T, Shiwaku H, Jitoku D, et al. Effect of tandospirone, a partial agonist of the 5-HT1A receptor, in a patient with chronic poststroke emotional incontinence with anxiousness. Prim Care Companion CNS Disord. 2019;21(5):18l02403. To share: https://doi.org/10.4088/PCC.18l02403 © Copyright 2019 Physicians Postgraduate Press, Inc. M and emotional disturbances might occur after a stroke and can be classified into several clinical phenotypes.1 Poststroke emotional incontinence (PSEI) is one of these clinical phenotypes and is characterized by excessive and inappropriate emotional expressions. A recent review1 posited that damage involving serotonergic fibers ascending from the raphe nuclei to the hemispheres is probably important in the pathogenesis of PSEI, and administration of selective serotonin reuptake inhibitors (SSRIs) is effective in treating PSEI in acute or subacute patients. To the best of our knowledge, however, there are no reports about patients with a chronic course of PSEI. We report a case in which tandospirone,2 a partial agonist of the 5-hydroxytryptamine-1A (5-HT1A; serotonin-1A) receptor, was effective for a poststroke patient with SSRI-resistant chronic emotional incontinence with anxiousness. The drug is a member of the azapirone class of drugs such as buspirone and gepirone.