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Neurological Abnormality Could be the First and Only Symptom of Familial Hemophagocytic Lymphohistiocytosis: Report of Two Families

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To the Editor: Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening disease which impacts many parts of the body including the digestive, circulatory, and respiratory systems. The central nervous system (CNS) can… Click to show full abstract

To the Editor: Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening disease which impacts many parts of the body including the digestive, circulatory, and respiratory systems. The central nervous system (CNS) can also be affected, particularly in patients with familial HLH‐2 (FHL‐2), responsible for approximately 20% of all FHL. FHL‐2 is a result of mutations to the perforin 1 (PRF1) gene, which can occur at numerous sites on the gene.[1]

Keywords: first symptom; lymphohistiocytosis; neurological abnormality; could first; hemophagocytic lymphohistiocytosis; abnormality could

Journal Title: Chinese Medical Journal
Year Published: 2018

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