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Squash cytodiagnosis of synchronous papillary serous carcinoma of ovary and endometrium with demonstration of serous tubal intraepithelial carcinoma as a precursor lesion

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Intraoperative cytodiagnosis is a very useful, simple, rapid, and cheap adjunctive technique for the intraoperative consultation of ovarian lesions.[1] In patients with suspected ovarian malignancy, it frequently can assist in… Click to show full abstract

Intraoperative cytodiagnosis is a very useful, simple, rapid, and cheap adjunctive technique for the intraoperative consultation of ovarian lesions.[1] In patients with suspected ovarian malignancy, it frequently can assist in performing optimum surgical management. Simultaneously occurring primary cancers of the female genital tract is a rare phenomenon accounting for 1%–6% of genital neoplasms. But out of these, synchronous endometrial and ovarian malignancies are frequently seen.[2] The two tumors can have similar morphology or may be of different types. It is extremely difficult to decide which one is primary and/or metastatic even though there are hypotheses suggesting either. The recent concept of ovarian serous carcinogenesis has changed over the last few decades and had nullified the previous theory of surface epithelial inclusion cysts. The fallopian tube has emerged as the culprit and more studies are being done to prove it without doubt. We describe here a case of synchronous ovarian and endometrial papillary serous carcinoma (high‐grade) which was diagnosed intraoperatively by squash cytology. The case was followed up, and serous tubal intraepithelial carcinoma (STIC) was demonstrated in both the fallopian tubes by histomorphology and immnuohistochemistry which could be the precursor lesion of ovarian serous carcinoma.

Keywords: carcinoma; intraepithelial carcinoma; tubal intraepithelial; serous carcinoma; papillary serous; serous tubal

Journal Title: Indian Journal of Pathology and Microbiology
Year Published: 2017

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