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Application of bi-nanoparticle on dose enhancement effect in two different polymer gel dosimeter using spectrophotometer

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Purpose: This study aimed at proving the ability of bismuth-nanoparticle (Bi-np) in dose enhancement effect (DEE) using the polymer gel dosimeter. Two different polymer gels, namely poly acrylamide gelatin tetrakis… Click to show full abstract

Purpose: This study aimed at proving the ability of bismuth-nanoparticle (Bi-np) in dose enhancement effect (DEE) using the polymer gel dosimeter. Two different polymer gels, namely poly acrylamide gelatin tetrakis hydroxymethyl phosphonium chloride (PAGAT) and N-isopropylacrylamide (NIPAM) gels were chosen for this study. Materials and Methods: The gels were doped with Bi-np particle with various concentrations of 0.5 mM, 1 mM, and 2.5 mM and were then irradiated with a CO-60 gamma radiation source of energy 1.25 MeV. Gel samples were analyzed by spectrophotometer. The dose enhancement factor (DEF) was calculated for both gels for all concentrations of Bi-np particle. Results: The higher DEF for PAGAT and NIPAM was calculated as 1.3415 and 1.1823, respectively, for 0.5 mM concentration of Bi-np. Conclusion: From our results, we infer that 0.5 mM is the optimal concentration in polymer gel to obtain good DEEs in the energy range of 1.25 MeV.

Keywords: nanoparticle dose; dose enhancement; enhancement effect; polymer gel

Journal Title: Journal of Cancer Research and Therapeutics
Year Published: 2018

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