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The pathological hallmark of PD is the presence of neuronal cytoplasmic inclusions called Lewy bodies (LB) or Lewy neurites, which consist of the abundant presynaptic protein alphasynuclein (α-syn) in an… Click to show full abstract
The pathological hallmark of PD is the presence of neuronal cytoplasmic inclusions called Lewy bodies (LB) or Lewy neurites, which consist of the abundant presynaptic protein alphasynuclein (α-syn) in an aggregated form. Apart from being present in all LB, α-syn is causally involved in rare cases of PD, where α-syn encoding SNCA gene either contains missense mutations or is duplior triplicated causing autosomal dominant familiar PD. Moreover, SNCA gene polymorphism is now believed to be a significant risk factor for the development of sporadic PD (Henderson et al., 2019).
Journal Title: Neural Regeneration Research
Year Published: 2021
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