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A novel approach in preventing vascular leakage and angiogenesis in wet age-related macular degeneration

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The blood vessels are composed of the monolayer of the endothelial cells, and the outer layer made by pericytes and smooth muscle cells provide structural support and shape to the… Click to show full abstract

The blood vessels are composed of the monolayer of the endothelial cells, and the outer layer made by pericytes and smooth muscle cells provide structural support and shape to the vessel. Endothelial monolayers function as a barrier. The barrier function of endothelial monolayers controls plasma protein uptake and the infiltration of immune cells by regulating adherence of cell-cell junction. Vascular leakage causes unwanted plasma leak, accumulation of immune cells, and tissue inflammation.

Keywords: leakage angiogenesis; novel approach; approach preventing; preventing vascular; vascular leakage; leakage

Journal Title: Neural Regeneration Research
Year Published: 2022

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