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Our study concludes that verapamil can be used as an adjunctive therapy to mitigate the damaging effect of tPA in hyperglycemic stroke. The current study only addressed the benefit of… Click to show full abstract
Our study concludes that verapamil can be used as an adjunctive therapy to mitigate the damaging effect of tPA in hyperglycemic stroke. The current study only addressed the benefit of verapamil in intraluminal filament model of middle cerebral artery occlusion to study the reperfusion independent toxicity of tPA. Further investigations are needed to confirm the beneficial effect of TXNIP inhibition on long term functional outcome in clinically relevant embolic model of middle cerebral artery occlusion with tPA recanalization.
Keywords:
verapamil;
therapeutic candidate;
verapamil possible;
candidate stroke;
repurposed therapeutic;
possible repurposed
Journal Title: Neural Regeneration Research
Year Published: 2022
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Journal Title: Neural Regeneration Research
Year Published: 2022
Link to full text (if available)
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recommendations!