LAUSR

mediated by TGFβ1 and TGFβ2 - during gliosis in mice. We also detected increased leucine zipper transcription factors (Tsc22), such as Tsc22d1, in Müller cells. In agreement with our findings, Tsc22 has been shown to sequester Smad7 from binding to activated Tgfbr1 and hinder Smad7/ Smurf-induced ubiquitination and degradation of the receptor (Xu, 2011). Tsc22 also promotes the expression of fibrotic genes, including PAI1 . Such as Tsc22, PAI1 signal was upregulated during the experiment only in murine Müller cells. Many pro-fibrotic genes were overexpressed after injury in murine Müller cells in our model, suggesting that gliosis can be considered a fibrotic-like process. these results show that TGFβ isoforms have different effects on tissue regeneration and degeneration, and the role of TGFβ may be context-dependent. TGFβ3 is related to retinal regeneration via canonical signaling upon the regulation of junb and mycb in zebrafish and are