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A potential new tool to enhance translational success rate in stroke research by backcrossing techniques in transgenic mice

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Ischemic stroke is a leading disease of the central nervous system, frequently coupled to severe damage and dysfunction in patients. Animal models mimicking human stroke provide useful tools for studying… Click to show full abstract

Ischemic stroke is a leading disease of the central nervous system, frequently coupled to severe damage and dysfunction in patients. Animal models mimicking human stroke provide useful tools for studying the pathomechanisms (e.g., inflammation, neuroprotection, and neural regeneration), the treatment efficiency of various materials (e.g., bioactive molecules or drugs), and transplantation usefulness by various cell types [e.g., neural stem/progenitor cells (NSPCs), and mesenchymal or hematopoietic stem cells] under ischemic stroke.

Keywords: potential new; new tool; enhance translational; tool enhance; translational success; research

Journal Title: Neural Regeneration Research
Year Published: 2022

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