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AxD is characterized by the formation of two morphological hallmarks, namely axonal fragments and axonal swellings. Whereas axonal fragments are separated segments of the axon resulting from axonal breakdown, axonal… Click to show full abstract
AxD is characterized by the formation of two morphological hallmarks, namely axonal fragments and axonal swellings. Whereas axonal fragments are separated segments of the axon resulting from axonal breakdown, axonal swellings are spherical structures that may emerge along the axon prior to the formation of axonal fragments (Palumbo et al., 2021). Quantifying these morphological hallmarks enables researchers to follow AxD over time, better understand differences in AxD kinetics, and assess candidate treatments.
Journal Title: Neural Regeneration Research
Year Published: 2022
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