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Introduction: Ever since the discovery of neural stem cells (NSCs) in the adult mammalian brain, scientists have been trying to decipher which signals govern their turnover and lineage commitment to… Click to show full abstract
Introduction: Ever since the discovery of neural stem cells (NSCs) in the adult mammalian brain, scientists have been trying to decipher which signals govern their turnover and lineage commitment to generate neurons and glia. Understanding their role in nervous tissue homeostasis can provide new insights into the etiology of several neurological disorders, and might one day be turned to our advantage to promote endogenous brain injury repair. Others and we have identified thyroid hormone (TH) as a key factor transcriptionally regulating NSC behavior in the largest niche of the adult mammalian brain: the subventricular zone (SVZ).
Journal Title: Neural Regeneration Research
Year Published: 2022
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