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Importance of TAU protein for dementia syndromes: Dementia currently affects about 55 million people worldwide, with Alzheimer ́s disease (AD) being the most prevalent form. The one crucial pathological hallmark… Click to show full abstract
Importance of TAU protein for dementia syndromes: Dementia currently affects about 55 million people worldwide, with Alzheimer ́s disease (AD) being the most prevalent form. The one crucial pathological hallmark of AD that correlates best with loss of synapses and cognitive decline are the so-called intracellular neurofibrillary tangles composed of mislocalized/missorted and hyperphosphorylated TAU protein (Naseri et al., 2019). Many other neurodegenerative diseases, both genetic and nongenetic, are characterized by neurofibrillary tangles or pathological accumulation of the protein TAU and are thus termed “tauopathies”. Tauopathies include AD and related aging-associated dementia syndromes like frontotemporal dementia and variants thereof (progressive supranuclear palsy, Pick‘s disease, corticobasal degeneration), but also childhood-onset genetic diseases (Zimmer-Bensch and Zempel, 2021).
Journal Title: Neural Regeneration Research
Year Published: 2022
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