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Synaptic alterations as a common phase in neurological and neurodevelopmental diseases: JNK is a key mediator in synaptic changes

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Brain synapses play a key role in neuronal communication: this “conversation” is at the basis of all brain activities and synaptic dysfunction leads to brain disorders. We study the modulators… Click to show full abstract

Brain synapses play a key role in neuronal communication: this “conversation” is at the basis of all brain activities and synaptic dysfunction leads to brain disorders. We study the modulators of this crucial synaptic function and we here present the evidence supporting the c-Jun N-terminal kinase (JNK) pathway as a pivotal actor in this scenario. The term “synapse” is derived from the Greek σύν (“together”) and ἅπτειν (“tap”, “connect”) meaning “conjunction”. Synapses are highly specialized cellular connections that represent the basic structural units of neuronal communication.

Keywords: common phase; neurodevelopmental diseases; synaptic alterations; alterations common; phase neurological; neurological neurodevelopmental

Journal Title: Neural Regeneration Research
Year Published: 2022

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