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microglia-specific effects induced by PLX5622, 2) non-physiological effects in compensating for microglia loss produced both by remaining microglia and other cells during PLX5622 treatment, 3) the rapid repopulation of microglia… Click to show full abstract
microglia-specific effects induced by PLX5622, 2) non-physiological effects in compensating for microglia loss produced both by remaining microglia and other cells during PLX5622 treatment, 3) the rapid repopulation of microglia with reduced chow consumption that accompanies increasing disease severity and 4) the use of additional corroborative experimental tools, including in vivo imaging, fate-mapping, single-cell transcriptomic or cytometric analysis of non-treated mice to validate depletion data.
Journal Title: Neural Regeneration Research
Year Published: 2022
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