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To The Editor, Lymphangioleiomyomatosis (LAM) is a chronic, progressive, and complex disease that almost always affects women. Women of childbearing age are frequently affected, albeit it is seen in the… Click to show full abstract
To The Editor, Lymphangioleiomyomatosis (LAM) is a chronic, progressive, and complex disease that almost always affects women. Women of childbearing age are frequently affected, albeit it is seen in the post‐menopausal age group as well. LAM has a prevalence of 1 to 5 in 10,00,000.[1] Somatic mutations in the TSC1 gene on chromosome 9q34 and TSC2 gene on chromosome 16p13.3 cause aberration in hamartin and tuberin proteins leading to the uninhibited proliferation of cells known as LAM cells.[1] The hallmark of pulmonary disease is the cystic remodeling of pulmonary parenchyma mediated by LAM cell‐derived matrix metalloproteinases.[1]
Journal Title: Annals of Cardiac Anaesthesia
Year Published: 2023
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