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Coexistence of NMDAR and CASPR2 Antibodies with HLA-B5 Positivity: A Puzzling Trilogy with Atypical Neuroimaging

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Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 5 ¦ September-October 2022 946 Sir, Autoimmune encephalitis has recently emerged as a major cause of neurologic morbidity, significantly… Click to show full abstract

Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 5 ¦ September-October 2022 946 Sir, Autoimmune encephalitis has recently emerged as a major cause of neurologic morbidity, significantly mediated by anti‐N‐methyl‐D‐aspartate receptor (NMDAR) antibodies. Characteristic clinical features include a combination of neurologic manifestations like seizures, memory disturbances, behavioral abnormalities, and movement disorders.[1] Auto‐antibodies against other proteins like contactin‐associated protein‐like 2 (CASPR2) are also associated with varied clinical presentations like limbic encephalitis, peripheral nerve hyperexcitability, cerebellar ataxia, seizures, and movement disorders.[2]

Keywords: nmdar; neurology; nmdar caspr2; caspr2 antibodies; coexistence nmdar

Journal Title: Annals of Indian Academy of Neurology
Year Published: 2022

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