LAUSR

Obviously, the primary differential diagnosis in patients with a pancreatic mass is cancer. Therapeutic options for cancer (surgery, chemotherapy radiotherapy) generally have potentially serious consequences. Therefore, management decisions in patients with cancer generally require diagnostic certainty. Cancer is a histological diagnosis, and histology requires a biopsy! C‐EUS would be of true value if it provided sufficient certainty to avoid biopsy – meaning it would have to be a very accurate and reproducible form of “optical biopsy.”