© 2019 International Journal of Critical Illness and Injury Science | Published by Wolters Kluwer ‐ Medknow Sepsis is defined as a life‐threatening organ dysfunction caused by a dysregulated host… Click to show full abstract
© 2019 International Journal of Critical Illness and Injury Science | Published by Wolters Kluwer ‐ Medknow Sepsis is defined as a life‐threatening organ dysfunction caused by a dysregulated host response to infection. Despite advances in medical therapy, sepsis‐associated morbidity and mortality remains high. Globally, sepsis‐associated mortality may be as high as 60%,[1] whereas in the United States, sepsis ranks among the leading causes of death by contributing to 33%–50% of in‐hospital deaths.[2] The financial strain that sepsis exerts on the medical system topped $24 billion in 2013,[3] a sharp rise from $20 billion just 4 years prior.[4]
               
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