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Sorafenib-induced grade III hand–foot skin reaction with ulcerative dermatitis on scrotum, penis, and earlobe

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Sir, A 60‐year‐old male with grade III hepatocellular carcinoma taking sorafenib 400 mg twice daily since 10 days was referred to the dermatology outpatient department for erosions and ulcerations on… Click to show full abstract

Sir, A 60‐year‐old male with grade III hepatocellular carcinoma taking sorafenib 400 mg twice daily since 10 days was referred to the dermatology outpatient department for erosions and ulcerations on scrotum, penis, and frictional zones like sacral areas and buttock. On dermatological examination, there were symmetrical erythematous patches with surface ulceration over groin, scrotum, penis, and gluteal region [Figure 1a and b]. In addition, erythematous plaques with central crusting and necrosis over bilateral earlobes were noted[Figure 1c and d]. On the background of decreased food intake due to hepatocellular carcinoma and clinical features, acquired zinc deficiency and sorafenib‐induced hand–foot skin reaction were suspected. However, during hospital stay he developed new erythematous patches with characteristic

Keywords: foot skin; scrotum penis; grade iii; dermatology; sorafenib induced; hand foot

Journal Title: Indian Journal of Dermatology, Venereology and Leprology
Year Published: 2019

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