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Early Recurrent Primary Membranous Nephropathy Detected in an Allograft Biopsy

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© 2018 Indian Journal of Nephrology | Published by Wolters Kluwer Medknow Sir, Recurrent primary membranous nephropathy (MN) is known to occur in renal allografts in about 40% cases, leading… Click to show full abstract

© 2018 Indian Journal of Nephrology | Published by Wolters Kluwer Medknow Sir, Recurrent primary membranous nephropathy (MN) is known to occur in renal allografts in about 40% cases, leading to graft dysfunction.[1] Recurrence is most common 2–3 years post–renal transplant but can occur as early as 1 week.[2] Protocol biopsies can reveal the recurrence before proteinuria develops.[1] In early cases, light microscopy (LM, including periodic acid–Schiff or silver stains) will not demonstrate diagnostic abnormalities; however, deposits can be detected by immunofluorescence (IF). Rodriguez EF et al. added Stage 0 in electron microscopic (EM) staging system, where deposits are seen only in IF.[3]

Keywords: nephrology; membranous nephropathy; early recurrent; primary membranous; recurrent primary

Journal Title: Indian Journal of Nephrology
Year Published: 2019

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