LAUSR

Systemic histoplasmosis is ubiquitous, and the causative fungus is found in the soil fertilized by birds, chicken, and bats.[1‐4] Histoplasmosis is common in immunosuppressed individuals and may present with mild influenza, which often leads to granulomatous disease and can even progress to life‐threatening disease.[1‐4] In developing countries such as India, it can mimic tuberculosis.[3,4] Ocular manifestations of systemic histoplasmosis include retinitis, choroiditis, optic neuritis, uveitis, and endophthalmitis.[1‐4] Presumed ocular histoplasmosis syndrome (POHS) may present with peripheral retinal or choroidal involvement called “histo spots,” and they mostly have clear vitreous, unlike systemic histoplasmosis.[1,2] POHS is mostly immunologic. Choroidal neovascular membrane is a known complication of histo spots in POHS.[1,2]