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Cystic fibrosis (CF) is caused by mutations in chromosome 7 that encodes the CFTR (cystic fibrosis trans membrane conductance regulator) gene, a chloride and bicarbonate ion transport channel responsible for… Click to show full abstract
Cystic fibrosis (CF) is caused by mutations in chromosome 7 that encodes the CFTR (cystic fibrosis trans membrane conductance regulator) gene, a chloride and bicarbonate ion transport channel responsible for maintaining osmotic balance across multiple epithelial surfaces in body.[1] This leads to multiple issues. First, xerophthalmia due to involvement of lacrimal gland. Second, vitamin A deficiency due to pancreatic insufficiency leading to keratomalacia. And third, increased susceptibility to Pseudomonas aeruginosa infection.
Journal Title: Indian Journal of Ophthalmology
Year Published: 2022
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