LAUSR

Sir, Autoantibody-mediated encephalitis (AME) is a neurological illness caused by autoantibodies of autoimmune or paraneoplastic pathology, directed against the neuronal surface, synaptic antigens, or the intracellular proteins. The onset is subacute, with the occurrence of altered mental status, seizures, and cognitive deficits, with a rapid progression. AME has been classified in different ways, including those based on anatomical sites involved or the underlying etiology, or eponymously classification too is present. One such terminology is limbic encephalitis (LE), where autoimmune or paraneoplastic affection of the limbic system is implicated as the etiology. LE can manifest with diverse psychopathology, including delusions, hallucinations, irritability, aggression, anxiety, depression, and catatonic symptoms. LE can also have atypical etiologies including nonparaneoplastic and seronegative varieties, especially during the early course of illness. Psychiatric presentations of atypical variants of LE are not reported in the existing literature.