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COVID-19 outbreak may increase mortality rates in genitourinary cancers

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COVID‐19 pandemic limits diagnosed cancer patients access to treatment each day globally. According to the data from the World Health Organization, cancer still remains as the biggest health issue with… Click to show full abstract

COVID‐19 pandemic limits diagnosed cancer patients access to treatment each day globally. According to the data from the World Health Organization, cancer still remains as the biggest health issue with 18 million new cases and 10 million mortalities annually. Among genitourinary cancers; excluding testicular tumor that is seen in younger age groups, average age is 70–75 years in prostate, bladder, and kidney cancer. One other common disease of the older age groups is hypertension (HT). The severe acute respiratory syndrome coronavirus 2 commonly referred as COVID‐19 appears to be associated with increased angiotensin‐converting enzyme 2 (ACE2) receptor levels in HT patients because of gaining ability to penetrate the membrane after binding to the ACE2 receptors on the cell membrane. The virus also binds to the TMPRSS2 receptor on the cell membrane and activates the camostate mesylate enzyme, making fusion and penetration easier in HT patients.[1] In addition to this, diabetes, cardiovascular diseases, and chronic respiratory diseases are common advanced age groups. Decreased kidney, liver and lung reserve, and decreased immunity are also important secondary complications.

Keywords: outbreak may; may increase; genitourinary cancers; age groups; age; covid outbreak

Journal Title: Urology Annals
Year Published: 2022

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