Photo by jonasjacobsson from unsplash
Aim: Two approaches based on molecularly imprinted polymers-stir bar sorptive extraction (MIP-SBSE) and -magnetic solid-phase extraction (MIP-MSPE) have been used for extraction of carbamazepine (CBZ) from serum samples. Methodology: In MSPE… Click to show full abstract
Aim: Two approaches based on molecularly imprinted polymers-stir bar sorptive extraction (MIP-SBSE) and -magnetic solid-phase extraction (MIP-MSPE) have been used for extraction of carbamazepine (CBZ) from serum samples. Methodology: In MSPE and SBSE, development was achieved by employing a polycaprolactam coating. The Cecil® chromatographic system equipped with a UV-Vis detector was used for analytical determination of CBZ. Results: The linearity of calibration curves was in the concentration ranges of 0.2-12 and 0.05-12 μg ml-1 for MIP-SBSE and MIP-MSPE, respectively. Conclusion: MIP-MSPE was selected in preference to MIP-SBSE since lower limits of detection were achievable using MIP-MSPE method. The CBZ-MIP-MSPE-HPLC-UV method was successfully applied to CBZ determination in real serum samples of patients receiving CBZ.
Journal Title: Bioanalysis
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!