LAUSR

A series of 1, 2, 4-triazole derivatives (1-17, Scheme 1) was synthesized and evaluated for their antimicrobial and antioxidant potential. Results of antimicrobial screening of the synthesized compounds indicated that most of the synthesized compounds showed good activity as compare to the norfloxacin as antibacterial and fluconazole as antifungal standard drugs. Compounds 7 and 12 were found to be most effective against various strains used for the antimicrobial activity like S. aureus, B. subtilis, E. coli, Candida albicans and A. niger using tube dilution method having MIC 3.12 μg/ml for S. aureus and 06.25 μg/ml for rest strains. All the synthesized compounds also evaluated for antioxidant activity by DPPH method and results revealed that the compounds 8 and 16 showed antioxidant activity comparable to the positive control ascorbic acid.