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Isatin is synthetically a versatile substrate that can be used for the synthesis of large variety of heterocyclic compounds. 5-substituted isatins were treated with 2-amino-5-chlorobenzo phenone to form Schiff’s bases.… Click to show full abstract
Isatin is synthetically a versatile substrate that can be used for the synthesis of large variety of heterocyclic compounds. 5-substituted isatins were treated with 2-amino-5-chlorobenzo phenone to form Schiff’s bases. Spirothiozolidin-4-ones and 5’-methyl-spiro-4-thiazolidiones were synthesized Schiff’s bases of isatins by treating with thioglycolic acid and thiolactic acid, respectively in the presence of 1,4-dioxane and anhydrous zinc chloride. The structures of the synthesized compounds were characterized by elemental and spectral analysis. These compounds were screened for their antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl method. Compound A02 found to possess potent antioxidant activity compared to the standards ascorbic acid and butylated hydroxytoluene.
Journal Title: Indian Journal of Pharmaceutical Sciences
Year Published: 2017
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