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Gold nanoparticles (GNPs) with controlled geometric properties are new options for the management of inflammatory responses and therapy for various diseases, including diabetes mellitus, rheumatoid arthritis, and connective tissue diseases.… Click to show full abstract
Gold nanoparticles (GNPs) with controlled geometric properties are new options for the management of inflammatory responses and therapy for various diseases, including diabetes mellitus, rheumatoid arthritis, and connective tissue diseases. We examined anti-inflammatory impacts of sugar coated GNPs with different sizes on carrageenan-induced rat paw inflammation. The synthesized GNPs were compared with indomethacin, methotrexate and the commercial gold preparation myochrysine. While methotrexate and myochrysine did not have any significant effects on rat paws, GNPs significantly decreased the inflammatory responses, comparable with indomethacin, a standard anti-inflammatory drug in the rat paw model. There was no harmful effect on metabolic activity
Journal Title: Genetics and Molecular Research
Year Published: 2018
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