LAUSR

*Corresponding author: [email protected] Tel./Fax: +7 (812) 234 57 20/+7 (812) 234 60 41 orcid.org/0000-0002-2826-3609 19.03.2021 02.08.2021 09.08.2021 Abstract Objectives: The aim of the present study is to develop a moisture protective coating solution and using it to film coat hygroscopic Herniaria glabra tablets. Materials and methods: Five coating formulations were developed and applied on Herniaria glabra core tablets by fluidized-bed coating. The film coated tablets were evaluated by appearance, percentage of moisture gain, disintegration time and percent of drug release. Physicochemical properties and stability during storage of the best obtained coated tablets were studied. Results: The results of this study showed that the film coating F5 containing 25% HPMC, 20% Shellac, 10% PEG 1500, 29.6% PEG 4000, 5% tween 80, 10% titanium dioxide and 0.4 % acid red 2 offered good protection for coated tablets against moisture. Coated tablets showed physical and dissolution stability during storage. Conclusion: Combination of hydrophilic polymer HPMC and hydrophobic polymer shellac is a suitable way to balance moisture protective properties and attain fast release of drugs. This study could make it useful to develop a pharmaceutical moisture barrier film coating system for immediate release tablets. However, more studies will be needed to further evaluate the moisture resistant film.