Photo by robbie36 from unsplash
Twenty new isatin-3-[N 2 -(benzimidazol-1-acetyl)]hydrazones ( IV ) were synthesized from ten different isatin-3-[N 2 –(chloroacetyl)] hydrazones ( III ) by reacting with benzimidazole and 2-methyl benzimidazole. The intermediates were… Click to show full abstract
Twenty new isatin-3-[N 2 -(benzimidazol-1-acetyl)]hydrazones ( IV ) were synthesized from ten different isatin-3-[N 2 –(chloroacetyl)] hydrazones ( III ) by reacting with benzimidazole and 2-methyl benzimidazole. The intermediates were obtained from isatin hydrazones ( II ) on condensation with chloroacetyl chloride. These compounds were characterized by IR, 1 H NMR and mass spectra. All the compounds were screened for antimicrobial, antioxidant and cytotoxic activity. Some of the new compounds showed promising antibacterial and antifungal activity. KEY WORDS : Antibacterial activity, Antifungal activity, Antioxidant activity, Cytotoxic activity, Benzimidazole, Isatin Bull. Chem. Soc. Ethiop. 2019 , 33(2), 321-329. DOI: https://dx.doi.org/10.4314/bcse.v33i2.12
Journal Title: Bulletin of the Chemical Society of Ethiopia
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!