LAUSR

Introduction: White pomegranate (P. granatum) is a species of the Punicaceae which is thought as hepatoprotector based on its antioxidant secondary metabolite compoundst. Aims: The purpose of study was to determine the hepatoprotector activity of white pomegranate fruit and seeds ethanol extract on male white rats Wistar strain. Methods: This research is laboratory experimental which rats were grouped into 5 groups randomly. Normal, negative (given Carboxymethylcellulose sodium 1% orally), test dose 1,2,3 (given extract at a dose of 50 mg /200 g bodyweight of rat, 100 mg/200 g bodyweight of rat and 200 mg/200 g bodyweight of rat in Carboxymethylcellulose sodium 1% orally). Negative, test dose 1,2,3 induced with paracetamol 180 mg/200 g bodyweight of rat. Results: From the statistical analysis, it was found that a significant difference between the negative with test dose 1, 2, and 3. The best hepatoprotector activity was produced by the test dose 3 with the percentage reduction in AST levels 91.62% and ALT 90.20%.