LAUSR

Introduction: Hypertensive disease can cause various complications, such as cardiovascular disease, stroke, diabetes mellitus, and kidney failure. To overcome these complications, patients are given polypharmacy therapy, which can potentially lead to drug interactions. Aim: The purpose of this study was to determine the potential incidence of drug interactions in hypertensive inpatients at the Persahabatan Hospital in 2015. Methods: The research is a descriptive study with retrospective data by purposive sampling technique using secondary data, medical records of hypertensive inpatients. The study of drug interactions was conducted theoretically, based on a literature study using Drug Interaction Facts 2014. Results: The results showed out of 174 hypertensive patients, 141 (81.0%) had potential drug interactions, with a total of 1444 cases. The highest drug interactions were at three levels of significance in 383 cases (26.5%), with 554 cases (38.4%) of pharmacodynamic mechanisms.