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482 Ann Dermatol Received September 13, 2018, Revised November 15, 2018, Accepted for publication January 2, 2019 Corresponding author: Young Min Park, Department of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea. Tel: 82-2-2258-6223, Fax: 82-2-599-9950, E-mail: [email protected] ORCID: https://orcid.org/0000-0002-3631-0807 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress. Pharm Res 2008;25:1355-1364. 5. Lee SH, Bae EA, Park EK, Shin YW, Baek NI, Han EJ, et al. Inhibitory effect of Eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. Int Immunopharmacol 2007;7:1678-1684. 6. Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, et al. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J Clin Invest 2004; 113:1168-1175. 7. Smith TM, Gilliland K, Clawson GA, Thiboutot D. IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway. J Invest Dermatol 2008;128:1286-1293. 8. Trivedi NR, Cong Z, Nelson AM, Albert AJ, Rosamilia LL, Sivarajah S, et al. Peroxisome proliferator-activated receptors increase human sebum production. J Invest Dermatol 2006; 126:2002-2009. 9. Ferré P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004;53 Suppl 1:S43-S50. 10. Choi Y, Jung Y, Kim SN. Identification of Eupatilin from Artemisia argyi as a selective PPARα agonist using affinity selection ultrafiltration LC-MS. Molecules 2015;20:1375313763.