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c 2018 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 24 No. 2 April, 2018 www.jnmjournal.org Irritable bowel syndrome (IBS) is the most representative disease that can be explained by the brain-gut axis. Psychiatric comorbidity plays an important role in the pathogenesis of IBS, which is frequently accompanied by depression and anxiety. A recent metaanalysis revealed that the prevalence of depression and anxiety was higher in patients with IBS, regardless of the IBS subtype, than in healthy people. Stress and sexual, physical, and emotional abuses are also important factors in the onset of IBS. While studies on the above-mentioned abnormal psychology in IBS have been actively conducted, there is little interest in positive psychology. In this issue of the Journal of Neurogastroenterology and Motility, Farhadi et al demonstrated that subjective well-being (SWB) and several well-being attributes are negatively associated with gastrointestinal symptoms and IBS. Of interest, this relationship is independent of anxiety and depression. To the best of knowledge, this is the first study to investigate the role of SWB, a positive psychology in patients with IBS. SWB, which may be an unfamiliar concept to gastroenterologists, is how people evaluate their lives emotionally and cognitively. Someone with a high level of SBW can be simply thought of as one who is very happy. Despite the high prevalence of IBS, its pathogenesis is not clear and no effective treatments have been developed until now. Therefore, a new approach is needed to overcome this problem. In this respect, this study suggests that SWB may be one of the pathogenic mechanisms of IBS. Some of the known risk factors for IBS could be understood in the relation with SWB. For example, marital status is an important factor for higher SWB, so married persons’ SWB is higher than that of those who are single or cohabiting. Similarly, single/divorced or widowed marital status has been known as an independent risk factor for higher medical utilization or overlap with functional dyspepsia in patients with IBS. We can also speculate that perceived stigmata commonly found in patients with IBS may decrease SWB. Several things should be considered before adopting SWB in clinical research and practice. SWB is a complex domain that combines various well-being attributes, so the SWB score may vary depending on the measurement methods and emotional state or situation at the point of measurement. SWB is closely related JNM J Neurogastroenterol Motil, Vol. 24 No. 2 April, 2018 pISSN: 2093-0879 eISSN: 2093-0887 https://doi.org/10.5056/jnm18053 Editorial Journal of Neurogastroenterology and Motility