LAUSR

120 mg/m2 on days 1 to 3. Treatment was delivered on an outpatient basis without the need of vigorous hydration. The preferred radiotherapy consisted of periventricular irradiation with an involved field boost. No spinal radiation was used. Conventional cranial irradiation was used instead of periventricular irradiation if the patient preferred a cheaper alternative. In eight children, two cycles of chemotherapy was used upfront followed by the radiotherapy and the remaining two cycles of chemotherapy were given four weeks after completion of irradiation. In the remaining two children, radiotherapy was used upfront followed by the four cycles of chemotherapy. An interim assessment by imaging was done after the second cycle of chemotherapy, prior to the radiotherapy if it had not been given, in all cases.