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Reply to Letter to the Editor: Critique of ‘‘Dramatical Response to Low-Dose Ultra-Slow Infusion of Alteplase for Massive Mitral Mechanical Valve Thrombosis’’

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As mentioned, acute ischemic stroke (AIS) is one of the deadliest complications of mitral valve thrombi. It has been reported in the literature that combined embolic events are seen at… Click to show full abstract

As mentioned, acute ischemic stroke (AIS) is one of the deadliest complications of mitral valve thrombi. It has been reported in the literature that combined embolic events are seen at rates ranging from nearly 1.5% to 20% in surgically treated patients and those receiving thrombolytic therapy. In the studies by “Hattusha”2 and “Prometee”3, 2.4% and 1.7% embolic events were observed, respectively, in the groups receiving low-dose ultra-slow thrombolytic therapy. Consistent with the literature, there is no definite information on how to approach embolic events that develop during treatment in these studies. In this step, individualized management is recommended considering both the severity of the complication and the residual valvular obstruction.

Keywords: embolic events; reply letter; valve; low dose; ultra slow; dose ultra

Journal Title: Anatolian Journal of Cardiology
Year Published: 2022

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