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5-Oxoproline acidosis caused by acetaminophen and flucloxacillin treatment - a case report.

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High anion gap metabolic acidosis (HAGMA) is a common diagnosis in the emergency department, which requires a systematic work-up in order to identify and treat the underlying cause. We present… Click to show full abstract

High anion gap metabolic acidosis (HAGMA) is a common diagnosis in the emergency department, which requires a systematic work-up in order to identify and treat the underlying cause. We present an unusual case of HAGMA due to 5-oxoproline accumulation caused by prolonged treatment with both acetaminophen (paracetamol) and flucloxacillin. This paper describes the diagnostic work-up of HAGMA and emphasizes on the approach and initial treatment in case the underlying etiology is unclear.

Keywords: treatment case; acidosis caused; oxoproline acidosis; case; treatment

Journal Title: Acute medicine
Year Published: 2022

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