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ALK-1-negative anaplastic large-cell lymphoma presenting as a dura-based mass in an infant.

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INTRODUCTION Anaplastic large-cell lymphoma (ALCL) rarely occurs in the central nervous system in the pediatric population. CASE PRESENTATION We describe a diagnostically challenging case of an 11-month-old infant presenting with… Click to show full abstract

INTRODUCTION Anaplastic large-cell lymphoma (ALCL) rarely occurs in the central nervous system in the pediatric population. CASE PRESENTATION We describe a diagnostically challenging case of an 11-month-old infant presenting with cranial nerve palsies and peripheral eosinophilia. Imaging demonstrated meningeal thickening with enhancement and dura-based deposits, the biopsy of which revealed features of ALK-1 negative ALCL on histologic and immunophenotypic analysis. A thorough investigation excluded the possibility of any extra-cranial origin. Hence, a diagnosis of "primary" ALCL was rendered. CONCLUSION ALCL arising in the dura in an infant has not been described earlier, to the best of our knowledge.

Keywords: alk negative; cell lymphoma; large cell; dura based; anaplastic large; infant

Journal Title: Clinical neuropathology
Year Published: 2021

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