LAUSR

Valerian, also known as Setwall, Valerianae radix, Phu belongs to Valerianaceae family. It is an herbaceous plant from Europe and Asian, present in almost all countries. The Valerian’s root is often used as herbal medicine. Valeriana officinalis is most commonly used as traditional medicine for 2000 years. Since 16th century until now, Valerian extracts has anxiolytic, hypnotic, tranquilizing, and sleep inducing effects that have been demonstrated in both animal studies and clinical trials. Valerian contains volatile oil (menoterpene bornyl acetate, sesquiterpenes, valerinic acid), valepotriates, hidroxy pinoresinol, alkaloid (actinidin, catinidin, valerianin, valerin), and glutamine. Glutamine cross the blood brain barrier which will then be converted into GABA inside GABA-nergic neurons. The primary component of Valerian officinalis is Valerenic acid with hydroxyl and acetone group derivatives, which inhibits catabolism enzyme induced breakdown of gamma amino butyric acid (GABA) in the brain resulting in sedation.1-6