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ADMET Prediction and In silico Analysis of Mangostin Derivatives and Sinensetin on Maltase-Glucoamylase Target for Searching Anti-Diabetes Drug Candidates

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Human Maltase-glucoamylase (MGA) is one type of alpha-glucosidase digestive enzyme in the human small intestine that works along with alpha-amylase and sucrose-isomaltase to digest carbohydrate and break it into glucose.4-10… Click to show full abstract

Human Maltase-glucoamylase (MGA) is one type of alpha-glucosidase digestive enzyme in the human small intestine that works along with alpha-amylase and sucrose-isomaltase to digest carbohydrate and break it into glucose.4-10 Thus enzyme that works together with sucrose-isomaltase to catalyze the final stages of starch digestion through hydrolyzing mixtures of dextrins at the non-reducting end into glucose with net retention of anomeric configuration. By inhibiting this enzyme, it is hoped that the starch digestive pathway can delay the production of glucose in type-II diabetes.1

Keywords: glucoamylase; prediction silico; analysis mangostin; maltase glucoamylase; admet prediction; silico analysis

Journal Title: Pharmacognosy Journal
Year Published: 2021

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