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Characterization and Acute Toxicity Bioactive Compound Canning Waste of Lemuru Fish Oil as Potential Immunomodulator

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Sardines are a group of small pelagic fishes which comes under the family Clupeidae. Sardinella longicep are well-known to be rich in long-chain polyunsaturated fatty acids (PUFA). Fish oil from… Click to show full abstract

Sardines are a group of small pelagic fishes which comes under the family Clupeidae. Sardinella longicep are well-known to be rich in long-chain polyunsaturated fatty acids (PUFA). Fish oil from a sardine species Sardinops melanostica has also been shown to inhibit microbial growth. Fish oil from Sardinella longicep is one type of animal oil derived from fish processing obtained in the coastal Muncar, Banyuwangi.1 The production is abundant, during this time the lemuru fish besides being made fish oil is also made a fish meal as livestock food. Lemuru fish oil can be used to meet energy sources in the feed because the energy contained in fat is 2.25 times greater than carbohydrate energy and protein.2 Lemuru fish oil contains n-3 polyunsaturated fatty acids (PUFA) namely eicosapentaenoic acid (EPA) and docohexasonoic acid (DHA).3 Eicosapentaenoic and DHA have a function in reducing the mediator of prostaglandin bone resorption (PGE2) and proinflammatory cytokines (IL-1α, IL-1β, TNF-α). If there is a decrease in PGE2, IL-1 and TNF-α, it will increase osteoblast activity and inhibit osteoclast formation in alveolar bone.4

Keywords: acute toxicity; fish oil; oil; toxicity bioactive; characterization acute; lemuru fish

Journal Title: Pharmacognosy Journal
Year Published: 2020

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