LAUSR

Manganese is an essential nutrient found in many plant foods, such as green tea beverages, unrefined cereals, legumes, and vegetables and is involved in various metabolic processes, such as bone formation, amino acid, cholesterol, and carbohydrate metabolism1). Therefore, a manganese deficiency has been reported to cause impaired growth, interfere with normal skeletal development, and alter lipid metabolism in various animal species1). Since there were insufficient data to set an Estimated Average Requirement in the Dietary Reference Intakes in North America1) and the Dietary Reference Intakes for Japanese (2020)2), the Adequate Intake (AI) (adult men and women: 2.3 and 1.8 mg/day in North America1) and 4.0 and 3.5 mg/day in Japan2), respectively) was set by estimating from the daily intake of people with normal dietary habits. The AI for Japanese people is slightly higher than that for North Americans because the Japanese diet contains more manganese source foods than the North American diet. As for manganese toxicity in humans, occupational exposure to inhaled manganese dust is known to the central nervous pathology. In the Dietary Reference Intakes in North America1), the Tolerable Upper Limit (UL) 11 mg/day was the amount of intake with no health effects set, based on the dietary intake of Western and vegetarian diets. The UL 11 mg/day was set in the Dietary Reference Intakes for the Japanese (2020)2) as well. Although Manganese is an essential nutrient, it is not assessed in the National Health and Nutrition Examination Survey Japan. Hence, the status of manganese intake in the Japanese population is left to individual research reports. The manganese intake of 31 adult Japanese men living in 31 prefectures in 1981–82 was 3.4 mg/day, as measured by inductively coupled plasma atomic emission spectroscopy from dry ash obtained by the duplicate portion method3). In other reports using duplicate portion methods from the early 1960s to the late 1980s, the range of intake for Japanese adults was 2.7-7.5 mg/day4). Rice and other cereals accounted for more than 50% of the food intake sources of manganese, followed by legumes, which contributed about 14%4). However, these studies had lesser subjects, even if the reports were based on samples drawn from all over Japan. Although the duplicate portion method is useful to accurately assess the amount of dietary and nutrient intake, it is difficult to implement in large epidemiological cohorts. Yamada et al.5) calculated the dietary intake of manganese in 120 women and 110 men aged 30–69 years using the semiquantitative dietary record method for 4 days of each season from November 2002 to September 2003, using the Standard Tables of Food Composition in Japan. The mean intake of manganese in men and women was 5.1 and 4.9 mg/day. The dietary sources that contributed to manganese intake were refined rice, green tea beverages, and vegetables (32%, 28%, and 13% in men; 24%, 34%, and 14% in women; respectively). The average intake of manganese up to 1990 4) in the reports and Yamada et al.5) cannot be compared because of the different assessment methods. Reports up to 1990 4) and Yamada et al.5) were in concordance that the principal dietary source of manganese was cereals. Although there is still a paucity of research reports on the association between manganese and cardiovascular and cardiometabolic diseases, inverse associations with type 2 diabetes6, 7) and metabolic syndrome risk8) have recently begun to be reported. Meishuo et al.9) estimated the manganese intake from the food frequency questionnaire (FFQ) and examined its association with cardiovascular disease mortality using the JACC study cohort data. Resultantly, they