LAUSR

BACKGROUND to investigate relationship between serum levels of A-kinase anchoring protein 1 (AKAP1) and T2DM. MATERIAL AND METHODS 261 subjects were involved in the experiment, including 130 patients with newly diagnosed T2DM and 131 people with normal glucose tolerance (NGT). They were further divided into four groups as follows. People with NGT and normal weight (NW) were assigned to NGT+NW group, with NGT but overweight(OW) or obesity(OB) assigned to NGT+OW/OB group, and the like, T2DM+NW group and T2DM+OW/OB group. Serum AKAP1 levels were tested by ELISA method and compared by T-test. Linear regression was applied to discuss independent factors of AKAP1. Multiple logistic regression was used to analyze relationship between AKAP1 and prevalence of T2DM. RESULTS serum AKAP1 in NGT+NW group was 1.74 ± 0.42ng/ml, higher than that in NGT+OW/OB group, 1.59 ± 0.41ng/ml (t = 2.114, P = 0.036); and T2DM+OW/OB group, 1.52 ± 0.36ng/ml (t = 3.219, P = 0.002). AKAP1 in 130 subjects with T2DM was lower than that in people with NGT, 1.57±0.35ng/ml vs. 1.67±0.42ng/ml, t = 2.036, P = 0.043. Liner regression showed that insulin resistance (IR) and body mass index (BMI) were independent factors negatively relalted to AKAP1, β=-0.019, -0.032, respectively. Compare to the highest tertile of AKAP1, the prevalence of T2DM was higher in other two tertiles, OR were 2.207 (1.203,4.050) and 2.051 (1.121,3.753), respectively. CONCLUSIONS serum AKAP1 level slightly decreases in people suffering T2DM and obesity. People with lower leve1s of serum AKAP1 are susceptible to T2DM.