LAUSR

INTRODUCTION This study presents a 10-years longitudinal assessment of bone status in adolescents and young adults with type 1 diabetes (T1D). MATERIALS AND METHODS Thirty two patients (12 female, aged 20.5±3.93 years, T1D duration 13.9±1.97 years) were studied using Quantitative Ultrasound (QUS) and Dual Energy X-ray Absorptiometry (DXA). Standard deviation scores (SDS) for these results were calculated. Following clinical parameters were analyzed: sex, age, T1D duration, anthropometric parameters, daily insulin requirement (DIR), mean of glycated hemoglobin (HbA1c) in the year preceding the examination, medication other than insulin, history of bone fractures and comorbidities. RESULTS The current and past (measured 10 years earlier) QUS results did not differ and showed a significant correlation (r=0.55, p=0.001). We found no relation of QUS results and anthropometric parameters or gender. DXA parameters did not correlate with the present QUS measurement. DXA and QUS results were independent from HbA1c, co-morbidities or additional medicaments intake. CONCLUSIONS Bone status parameters of the examined patients with currently suboptimal glycemic control were found to be lowered in comparison to normative reference population, both at baseline and follow-up, although no further deterioration was observed during the 10-year follow-up period.