LAUSR

It is already known that the discovery of kisspeptin was a revolutionary step in the understanding of regulation of neuroendocrine in reproduction. Kisspeptin is one of the main moderators of the gonadotropic axis, but the kisspeptin gene is known to be expressed in various regions of the central nervous system. The activity of kisspeptin is not limited to hypothalamic pituitary gonadal (HPG) axis; it participates in the regulation of multiple neuronal circuits in the limbic system. The limbic system is a part of the brain involved in behavioral and emotional reactions, and disturbances in its functioning may be a source of some psychiatric as well as degenerative disorders. In the present review, we summarize the current state of knowledge concerning the role of kisspeptin in the limbic system and a new hope for the treatment of disturbances in its functioning.