LAUSR

Sodium glucose co-transporter-2(SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and thiazolidinediones are effective oral anti-diabetic agents used in treatment of type 2 Diabetes Mellitus. Therefore, the necessity to exploreand compare the existing analytical and bioanalytical assays used for determination of such drugs either single or in combination is crucial. Many methods were reported in the literature for the bio-analysis and analysis of two novel gliptins ’combinations, empagliflozin-linagliptin combination with application on Glyxambi®tablets and alogliptin-pioglitazone combination with application on Oseni® tablets. Furthermore, this review offered an overview of different methods used for determination of every drug alone asempagliflozin from SGLT-2 inhibitors, Alogliptin and linagliptin from DPP-4 inhibitors and pioglitazone from thiazolidinedionesin a tabulated comparative way. Moreover, the present review emphasized the most common stability indicating assaysto be of interest to the analysts in the area of drug control.