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Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers

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Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes,… Click to show full abstract

Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.

Keywords: genitourinary cancers; exosomes genitourinary; cancers emerging; drug; drug resistance

Journal Title: International Journal of Biological Sciences
Year Published: 2023

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